Women Genetically More Prone to Depression, Finds Global Study
Women Genetically More Prone to Depression, Finds Global Study
Study reveals females have nearly twice as many genetic markers linked to depression as men, highlighting urgent need for gender-sensitive mental health policies
Women across the world are nearly twice as likely to suffer from depression as men — and genetics may be one of the key reasons. A groundbreaking study led by Australia’s Berghofer Medical Research Institute has revealed that women carry almost double the number of genetic markers linked to depression compared to men.
Published in Nature Communications, the research is among the largest of its kind, analysing DNA from nearly 200,000 people diagnosed with major depression — around 130,000 women and 65,000 men. Lead neuro-geneticist Dr. Jodi Thomas said the findings confirm that “the genetic component to depression is larger in females compared to males,” suggesting biological vulnerability may partly explain the mental health gender gap.
The study also found genetic differences that could explain why women with depression more often experience metabolic symptoms such as weight fluctuations and low energy levels.
Global data supports this disparity. According to the World Mental Health Today report, 581.5 million women were living with a mental health disorder in 2021, compared with 513.9 million men. The World Health Organization estimates depression is 1.5 times more common in women, affecting 6.9 per cent of women versus 4.6 per cent of men worldwide.
Other patterns reveal gendered tendencies across mental health conditions:
- Depressive disorders: 64.9% women, 35.1% men
- Anxiety disorders: 62.6% women, 37.4% men
- Eating disorders: 63.3% women, 36.7% men
Experts say bridging this gap demands stronger gender-sensitive mental health policies, better support during pregnancy and postpartum, and integrating mental health care in domestic violence and workplace reforms.
They stress that addressing women’s mental health is not only a fairness issue but also crucial for stronger families, healthier economies, and resilient societies.
Disclaimer: This article is for informational purposes only. Always consult a qualified healthcare professional for medical advice.
